Detalhe da pesquisa
1.
Sterile protection against human malaria by chemoattenuated PfSPZ vaccine.
Nature
; 542(7642): 445-449, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28199305
2.
Increase of Dose Associated With Decrease in Protection Against Controlled Human Malaria Infection by PfSPZ Vaccine in Tanzanian Adults.
Clin Infect Dis
; 71(11): 2849-2857, 2020 12 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31782768
3.
Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection.
Proc Natl Acad Sci U S A
; 114(10): 2711-2716, 2017 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28223498
4.
Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution.
Bioorg Med Chem Lett
; 20(16): 4836-9, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20634066
5.
Safety and Differential Antibody and T-Cell Responses to the Plasmodium falciparum Sporozoite Malaria Vaccine, PfSPZ Vaccine, by Age in Tanzanian Adults, Adolescents, Children, and Infants.
Am J Trop Med Hyg
; 100(6): 1433-1444, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30994090
6.
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.
Bioorg Med Chem
; 16(23): 10049-60, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18952439
7.
Impact of Sickle Cell Trait and Naturally Acquired Immunity on Uncomplicated Malaria after Controlled Human Malaria Infection in Adults in Gabon.
Am J Trop Med Hyg
; 98(2): 508-515, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29260650
8.
Advancing Global Health through Development and Clinical Trials Partnerships: A Randomized, Placebo-Controlled, Double-Blind Assessment of Safety, Tolerability, and Immunogenicity of PfSPZ Vaccine for Malaria in Healthy Equatoguinean Men.
Am J Trop Med Hyg
; 98(1): 308-318, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29141739
9.
Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults.
Am J Trop Med Hyg
; 99(2): 338-349, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29943719
10.
Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial.
Lancet Infect Dis
; 17(5): 498-509, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28216244
11.
Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.
JCI Insight
; 2(1): e89154, 2017 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28097230
12.
Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.
Nat Med
; 22(6): 614-23, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27158907
13.
Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine.
Science
; 341(6152): 1359-65, 2013 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23929949
14.
Corrigendum: Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.
Nat Med
; 22(6): 692, 2016 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27270781
15.
Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.
Bioorg Med Chem Lett
; 17(11): 3048-52, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17400453
16.
Overcoming roadblocks in lead optimization: a thermodynamic perspective.
Chem Biol Drug Des
; 67(1): 2-4, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16492143